“Modeling of the production of lipid microparticles using PGSS technique” published in Molecules Journal

The Particles from Gas-Saturated Solutions (PGSS®) technique is a one-step and solvent-free process that allows for the encapsulation of thermolabile substances with pharmaceutical, cosmetic and food processing purposes. Several variables can influence the overall performance of the process, as well as the morphology and size of the particles.

In a research carried out by the I+D Farma group in collaboration with NAFOMAT group, the range of conditions for the PGSS processing of the lipid glyceryl monostearate was determined in melting point depletion studies. Batches of the particles were produced using different combinations of conditions based on an experimental design, and the particles were analysed. Artificial intelligence tools were used to model the results and study the influence of the processing variables on the processability and characteristics of the particles.

The work was entitled Modelling of the production of lipid microparticles using PGSS technique and published in Molecules journal in October 2020.